• Resource-Efficient Use of Residues from Medicinal and Aromatic Plants for Production of Secondary Plant Metabolites

• Digital Twin Fundamentals of mRNA In Vitro Transcription in Variable Scale Toward Autonomous Operation

• Biopharma 4.0 for Biologics Manufacturing Under Pandemic Constraints
  

• Autonomous Hydrodistillation with a Digital Twin for Efficient and Climate Neutral Manufacturing of Phytochemicals

• Digital Twin Enabled Process Development, Optimization and Control in Lyophilization for Enhanced Biopharmaceutical Production

 

 

2023

• Continuous Biomanufacturing in Upstream and Downstream Processing

• Is Regulatory Approval without Autonomous Operation for Natural Extract Manufacturing under Economic Competitiveness and Climate-Neutrality Demands Still Permissible?

• Formulation of Nucleic Acids by Encapsulation in Lipid Nanoparticles for Continuous Production of mRNA

• Residence Time Section Evaluation and Feasibility Studies for
  One-Column Simulated Moving Bed Processes (1-SMB)

• Multivariate Parameter Determination of Multi-Component Isotherms for Chromatography Digital Twins

• Digital Twin Based Design and Experimental Validation of a Continuous Peptide Polishing Step

• Effect of the Freezing Step on Primary Drying Experiments and Simulation of Lyophilization Processes

• Benefits and Limitations of Artificial Neural Networks in Process Chromatography Design and Operation

• Establishment of a Research Focus on Resilient Sustainable Climate Neutral Agricultural Production—Resilient Farming Initiative

• Scalable mRNA Machine for Regulatory Approval of Variable Scale between 1000 Clinical Doses to 10 Million Manufacturing Scale Doses

• Autonomous Liquid-Liquid Extraction Operation in Biologics Manufacturing with Aid of a Digital Twin including Process Analytical Technology
  

• Green Manufacturing for Herbal Remedies with Advanced Pharmaceutical Technology
  

 

2022

• Emerging PAT for Freeze-Drying Processes for Advanced Process Control 
  

•  Towards Autonomous Process Control - Digital Twin for HIV-Gag VLP Production in HEK293 Cells Using a Dynamic Metabolic Model 
  

• Toward Autonomous Production of mRNA-Therapeutics in Light of Advanced Process Control and Traditional Control Strategies for Chromatography 
  

• Process Automation and Control Strategy by Quality-by-Design in Total Continuous mRNA Manufacturing Platforms
  

• Development of Concepts for a Climate-Neutral Chemical-Pharmaceutical Industry in 2045
  

• Digital Twin for HIV-Gag VLP Production in HEK293 Cells
  

• Digital Twins for scFv Production in Escherichie coli
  

• Need for a Next Generation of Chromatography Models - Academic Demands for Thermodynamic Consistency and Industrial Requirements in Everyday Project Work
  

• Artificial Neuronal Network for Fast and Versatile Model Parameter Adjustment Utilizing PAT Signals of Chromatography Processes for Process Control under Production conditions 
  

• Proposal of a New Green Process for Waste Valorization and Cascade Utilization of Essential Oil Plants
  

• Versatile Green Processing for Recovery of Phenolic Compounds from Natural Product Extracts towards Bioeconomy and Cascade Utilization for Waste Valorization on the Example of Cocoa Bean Shell (CBS)

• Climate Neutrality Concepts for the German Chemical-Pharmaceutical Industry
  

• Process Design and Optimization towards Digital Twins for HIV-Gag VLP Production in HEK293 Cells, including Purification

• Enabling Total Process Digital Twin in Sugar Refining through the Integration of Secondary Crystallization Influences

• Towards Autonomous Process Control - Digital Twin for CHO Cell-Based Antibody Manufacturing Using a Dynamic Metabolic Model
  

• Current Trends and uture Developments on (Bio-) Membranes

2021

• Digital Twins for Continuous Biologics Manufacturing
  

• Process Analytical Technology as Key-Enabler for Digital Twins in Continuous Biomanufacturing
  

• Fast and Versatile Chromatography Process Design and Operation Optimization with the Aid of Artificial Intelligence
  

• Development of a general PAT Strategy for Online Monitoring of complex Mixtures - on the Example of Natural Product Extracts from bearberry leaf (Arctostaphylos uva-ursi)
  

• Digital Twins for Continuous mRNA Production
  

• Fast and Flexible mRNA Vaccine Manufacturing as a Solution to Pandemic Situations by Adopting Chemical Engineering Good Practice - Continuous Autonomous Operation in Stainless Steel Equipment Concepts
  

• Advanced Process Analytical Technology in Combination with Process Modeling for Endpoint and Model Parameter Determination in Lyophilization Process Design and Optimization
  

• Präparative Chromatographie von (Bio-)Pharmazeutika - Mit digitalisierten Mehrzweckanlagen zu schnellen und flexiblen Prozessen
  

• Digital Twin of mRNA-Based SARS-COVID-19 Vaccine Manufacturing towards Autonomous Operation for Improvements in Speed, Scale, Robustness, Flexibility and Real-Time Release Testing
  

• Process Analytical Technology for Precipitation Process Integration into Biologics Manufacturing towards Autonomous Operation—mAb Case Study

• PAT for Continuous Chromatography Integrated into Continuous Manufacturing of Biologics towards Autonomous Operation

• Towards Autonomous Operation by Advanced Process Control - Process Analytical Technology for Continuous Biologics Antibody Manufacturing
  

• Special Issue "Towards Autonomous Operation of Biologics and Botanicals"
  

• Application and Fundamentals of Liquid-Liquid Extraction Processes: Purification of Biologics, Botanicals, and Strategic Metals (Wiley-VCH, Weinheim, September 2018)

  A. Schmidt, J. Strube

  Article first published online: 19 SEP 2018| DOI: 10.1002/0471238961.koe00041

 

2016

• Production of Plant Extracts–from Evolution to Revolution Resource Efficient Manufacturing in Regulated Industries (Bericht aus dem JKI, Nr. 183, 2016)

  J. Strube, M. Tegtmeier

• Model-based systematic interpretation of the extraction and purification of 10-deacetylbaccatin III from Taxus baccata.(Bericht aus dem JKI, Nr. 183, 2016)

  I. Koudous, M. Sixt, J. Strube

• Use non-invasive analytical methods in the characterization of vegetable raw materials and in process control. (Bericht aus dem JKI, Nr. 183, 2016)

  G. Gudi, A. Krähmer, H. Krüger, I. Koudous, J. Strube, H. Schulz

• Einsatz nicht-invasiver Analysemethoden bei der charakterisierung pflanzlicher Rohstoffe und in der Prozesskontrolle(Bericht aus dem JKI, Nr. 183, 2016)

  G. Guci, A. Krähmer, H. Krüger, I. Koudous, J. Strube, H. Schulz

• Process design for integration of extraction, purification and formulation with alternative solvent concepts (Comptes Rendus Chimie, Volume 19, Issue 6, June 2016, Pages 733-748)

  M. Sixt, I. Koudous, J. Strube

  Article first published online: 04 MAY 2016 | DOI: 10.1016/j.crci.2015.12.016

• Preparation and characterization of high capacity, strong cation-exchange fiber based adsorbents (Journal of Chromatography A, Volume 1447, May 2016, Pages 92-106)

  J. Schwellenbach, F. Taft, L. Villain, J. Strube

  Article first published online: 20 MAY 2016 | DOI: 10.1016/j.chroma.2016.04.019

• Implementation of aqueous two-phase extraction combined with precipitation in a monoclonal antibody manufacturing process (Chimica Oggi-Chemistry Today, Volume 34, Issue 3, JUN 2016, Pages 66-70)

  P. Gronemeyer, R. Ditz., J. Strube

• Controlling the polymer-nanolayer architecture on anion-exchange membrane adsorbers via surface-initiated atom transfer radical polymerization (Reactive and Functional Polymers, Volume 106, September 2016, Pages 32-42

  J. Schwellenbach, P. Kosiol, B. Sölter, F. Taft, L. Villain, J. Strube

  Article first published online: JUL 2016 | DOI: 10.1016/j.reactfunctpolym.2016.07.005

• DoE based integration approach of upstream and downstream processing regarding HCP and ATPE as harvest operation (Biochemical Engineering Journal, Volume 113, SEPTEMBER 2016, Pages 158-166)

  P. Gronemeyer, R. Ditz, J. Strube

  Article first published online: 15 SEP 2016 | DOI: 10.1016/j.bej.2016.06.016

• Purification of Monoclonal Antibodies Using a Fiber Based Cation-Exchange Stationary Phase: Parameter Determination and Modeling (Bioengineering, Volume 3, Issue 4, 24)

  J. Schwellenbach, S. Zobel, F. Taft, L. Villain, J. Strube

  Article first published online: 02 OCT 2016 | DOI: 10.3390/bioengineering3040024

• Straightforward process for the identification and isolation of natural products using thin-layer and preparative chromatography (Planta Medica, Volume 81, Issue 1, December 2016, Pages 112)

  M. Schulte, M. Oberle, M. Sixt, J. Strube

  Article first published online: DEC 2016 | DOI: 10.1055/s-0036-1596278

 

2015

• Characterization Method for Separation Deices Based on Micro Technology (Chemie Ingenieur Technik, Volume 87, Issue 1-2, February 2015, Pages 150-158)

  T. Wellsandt, B. Stanisch, J. Strube

  Article first published online: 13 JAN 2015| DOI: 10.1002/cite.201300184

• Green Extraction of Natural Products: Theory and Practice (Wiley-VCH, Weinheim, March 2015 )

  F. Chemat, J. Strube

  ISBN: 978-3-527-33653-1

• 2. Process Engineering and Product Design for Green Extraction (Green Extraction of Natural Products, Wiley-VCH, Weinheim, March 2015 )

  S. Both, R. Ditz, M. Tegtmeier, U. Jenelten, J. Strube

  Article first published online: 06 FEB 2015| DOI: 10.1002/9783527676828.ch2

• 4. Mass Transfer Enhancement for Solid–Liquid Extractions (Green Extraction of Natural Products, Wiley-VCH, Weinheim, March 2015 )

  S. Both, J. Strube, G. Cravatto

  Article first published online: 06 FEB 2015| DOI: 10.1002/9783527676828.ch4

• 6. Panorama of Sustainable Solvents for Green Extraction Processes (Green Extraction of Natural Products, Wiley-VCH, Weinheim, March 2015 )

  I. Koudous, W. Kunz, J. Strube

  Article first published online: 06 FEB 2015| DOI: 10.1002/9783527676828.ch6

• Infrared and Raman spectroscopic methods for characterization of Taxus baccata L.--Improved taxane isolation by accelerated quality control and process surveillance. (Talante, Volume 143, October 2015, Pages 42-49)

  G. Gudi, A. Krähmer, I. Koudous, J. Strube, H. Schulz

  Article first published online: 08 MAY 2015| DOI: 10.1016/j.talanta.2015.04.090

• Development of Micro Separation Technology Modules. Part 1: Liquid-Liquid Extraction (Chemie Ingenieur Technik, Volume 87, Issue 9)

  T. Wellsandt, B. Stanisch, J. Strube

  Article first published online: 08 JUL 2015| DOI: 10.1002/cite.201400074

• Development of micro separation technology modules – Part 2: Distillation (Chemie Ingenieur Technik, Volume 87, Issue 9)

  T. Wellsandt, B. Stanisch, J. Strube

  Article first published online: 17 JUL 2015| DOI: 10.1002/cite.201400075

• Purification of Antibodies and their Fragments by ATPE and Precipitation: One Step towards a Chromatography-Free Manufacturing Process (Chemie Ingenieur Technik, Volume 87, Issue 8, August 2015, Pages 1057-1058)

  P. Gronemeyer and J. Strube

  Article first published online: 28 JUL 2015| DOI: 10.1002/cite.201550107

• Modellbasierte systematische Auslegung der Extraktion und Aufreinigung von 10-Deacetylbaccatin III aus Taxus baccata (Chemie Ingenieur Technik, Volume 87, Issue 8, August 2015, Pages 1084ff)

  M. Sixt, I. Koudous, J. Strube

  Article first published online: 28 JUL 2015 | DOI: 10.1002/cite.201550014

• Development of Purification Concepts for Nutraceuticals from Algae – Part I: Characterization of Emulsifying Components (Chemical Engineering & Technology, Volume 38, Issue 11, November 2015, Pages 2025-2034)

  H. Fröhlich, K. Gasser, S. Gaul, T. Grützner, J. Strube

  Article first published online: 13 OCT 2015 | DOI: 10.1002/ceat.201400619

• Development of Purification Concepts for Nutraceuticals from Algae – Part II: Design of Purification Strategies (Chemical Engineering & Technology, Volume 38, Issue 11, November 2015, Pages 2035-2044)

  H. Fröhlich, K. Gasser, S. Gaul, T. Grützner, J. Strube

  Article first published online: 06 OCT 2015 | DOI: 10.1002/ceat.201400618

• Technological and methodical process integration in manufacturing of monoclonal antibodies (BMC Proceedings, Volume 9, Supplement 9, December 2015, Page 39)

  P. Gronemeyer and J. Strube

  Article first published online: 14 DEC 2015| DOI: 10.1186/1753-6561-9-S9-P39

 

2014

• Design and Operation of Continuous Countercurrent Chromatography in Biotechnological Production (Ind. Eng. Chem. Res., Volume 53, Issue 22, January 2014, Pages 9169–9185)

  S. Zobel, C. Helling, R. Ditz and J. Strube

  Article first published online: 6 JAN 2014| DOI: 10.1021/ie403103c

• Model-based equipment-design for plant-based extraction processes – considering botanic and thermodynamic aspects (Comptes Rendus Chimie, Volume 17, Issue 3, March 2014, Pages 187-196)

  S. Both, I. Koudous, U. Jenelten, J. Strube

  DOI: 10.1016/j.crci.2013.11.004

• Efficient Engineering and Production Concepts for Products in Regulated Environments – Dream or Nightmare? (Chemie Ingeniuer Technik, Volume 86, Issue 5, May 2014, Pages 687-694)

  J. Strube, R. Ditz, H. Fröhlich, D. Köster, T. Grützner, J. Koch, R. Schütte

  Article first published online: 07 APR 2014| DOI: 10.1002/cite.201300081

• Herbal extract production - From evolution to revolution (ZEITSCHRIFT FÜR ARZNEI UND GEWÜRZPFLANZEN, Volume 19, Issue 4, 2014, Pages 169-192)

  S. Both, M. Tegtmeier, J. Strube

• Process design based on physicochemical properties for the example of obtaining valuable products from plant based extracts (Comptes Rendus Chimie Volume 17, Issue 3, March 2014, Pages 218–231)

  I. Koudous, S. Both, G. Gudi, H. Schulz, J. Strube

  Article first published online: 16 JAN 2014| DOI: 10.1016/j.crci.2013.11.003

• Multi-Stage Aqueous Two-Phase Extraction for the Purification of Monoclonal Antibodies (Chemical Engineering & Technology, Volume 37, Issue 4, pages 675–682, April 2014)

  J. K. Eggersgluess, M. Richter, M. Dieterle and J. Strube

  Article first published online: 28 FEB 2014| DOI: 10.1002/ceat.201300604

• Panorama of Sustainable Solvents for Green Extraction Processes (Green Extraction of Natural Products. Wiley-VCH, Weinheim, 173-236)

  F. Chemat, J. Strube

• Prozessentwicklung durch Integration von Upstream und Downstream Processing für biologisch aktive Substanzen (Chemie Ingenieur Technik, Volume 85, Issue 9, September 2013, Page 1408)

  P. Gronemeyer, J. Eggersglüß and J. Strube

  Article first published online: 23 AUG 2014| DOI: 10.1002/cite.201250623

• Prozessintegration der Kristallisation in das Downstream-Processing von Pharmazeutika (Chemie Ingenieur Technik, Volume 86, Issue 9, September 2014, page 1499)

  M. Lucke, I. Koudous and J. Strube

  Article first published online: 28 AUG 2014| DOI: 10.1002/cite.201450484

• Entwicklung eines industrierelevanten Ansatzes zur Modellierung von Pervaporationen (Chemie Ingenieur Technik, Volume 86, Issue 9, September 2014, page 1453)

  H. Thiess, B. C. Seyfang, T. Grützner and J. Strube

  Article first published online: 28 AUG 2014| DOI: 10.1002/cite.201450483

• Integration der Prozessentwicklung von Upstream und Downstream Processing (Chemie Ingenieur Technik, Volume 86, Issue 9, September 2014, Page 1491)

  P. Gronemeyer and J. Strube

  Article first published online: 28 AUG 2014| DOI: 10.1002/cite.201450255

• Integrated Counter Current Chromatography (iCCC) – Von der SMB zum integrierten Prozess (Chemie Ingenieur Technik, Volume 86, Issue 9, September 2014, Page 1504)

  S. Zobel, C. Helling and J. Strube

  Article first published online: 28 AUG 2014| DOI: 10.1002/cite.201450275

• Integration of Aqueous Two-Phase Extraction into Downstream Processing (Chemical Engineering & Technology, Volume 37, Issue 10, October 2014, Pages 1686-1696)

  J. Eggersglüss, T. Wellsandt, J. Strube

  Article first published online: 09 SEP 2014| DOI: 10.1002/ceat.201400114

• Trends in Upstream and Downstream Process Development for Antibody Manufacturing (Bioengineering, Volume 1, Issue 4, pages 188-212, October 2014)

  P. Gronemeyer, R. Ditz and J. Strube

  Article first published online: 1 OCT 2014| DOI:10.3390/bioengineering1040188

• Regulatorische Anforderungen an die Produktion und Qualität pflanzlicher Arzneimittel (Julius-Kühn-Archiv)

  H. Hagels, M. Tegtmeier, J. Strube

  DOI: 10.5073/jka.2014.446.015

• Qualität von Anfang an – Voraussetzung für Extrakte höchster Güte (Julius-Kühn-Archiv)

  M. Tegtmeier, H. Hagels, J. Strube

  DOI: 10.5073/jka.2014.446.021

 

2013

• QBD in process design for phytoextracts (Planta Med, 79 WS24, 2013)

  M. Tegtmeier, J. Strube, S. Both, H. Hagels

  DOI: 10.1055/s-0033-1351825

• GACP regulation for herbal raw materials (Planta Med, 79 WS24, 2013)

  M. Tegtmeier, J. Strube, S. Both, H. Hagels

  DOI: 10.1055/s-0033-1351823

• Physical characterization of column chromatography: stringent control over equipment performance in biopharmaceutical production, Trends in Chromatography (Chemie Ingenieur Technik Special Issue: Membranen und Membranprozesse Volume 85, Issue 8, Pages 55-71)

  C. Helling, T. Dams, B. Gerwat, A. Belousov, J. Strube

• Resource‐Efficient Process Technology for Energy Plants (Chemie Ingenieur Technik Volume 85, Issue 8, pages 1282–1289)

  S Both, C Helling, J Namyslo, D Kaufmann, B Rother, H Harling, J Strube

  Article first published online: 4 JUN 2013| DOI: 10.1002/cite.201200205

• Future Processing and Recycling Strategies for Rare Earths (Chemie Ingenieur Technik Special Issue: Membranen und Membranprozesse Volume 85, Issue 8, Pages 1272-1281)

  C Helling, J Strube

  Article first published online: 10 JUN 2013| DOI: 10.1002/cite.201200214

• Optimizing Established Processes like Sugar Extraction from Sugar Beets – Design of Experiments versus Physicochemical Modeling (Chemical Engineering & Technology Volume 36, Issue 12, Pages 2125–2136)

  S. Both, J. Eggersglüß, A. Lehnberger, T. Schulz. T. Schulze, J. Strube

  Article first published online: 25 OCT 2013| DOI: 10.1002/ceat.201300484

• Extraction of polyphenols from black tea - conventional and ultrasound assisted extraction (Ultrasonics Sonochemistry, Pages 1030-1034)

  S. Both, F. Chemat, J. Strube

  Article first published online: 21 NOV 2013| DOI: 10.1016/j.ultsonch.2013.11.005

 

2012

 

• Combination of Rigorous and Statistical Modeling for Process Development of Plant Based Extractions Based on Mass Balances and Biological Aspects (Chemical Engineering & Technology, Special Issue: Preparative Chromatography and Downstream Processing, Volume 35, Issue 1, pages 109-132)

  M. Kaßing, U. Jenelten, J. Schenk, J. Strube

  Article first published online: 28 DEC 2011 | DOI: 10.1002/ceat.201100268

• Integration of Reverse-Osmosis Unit Operations in Biotechnology Process Design (Chemical Engineering & Technology, Special Issue: Preparative Chromatography and Downstream Processing, Volume 35, Issue 1, pages 191-197)

  F. Grote, H. Fröhlich, J. Strube

  Article first published online: 15 DEC 2011 | DOI: 10.1002/ceat.201100182

• Downstream of Downstream Processing: Development of Recycling Strategies for Biopharmaceutical Processes (Journal of Chemical Technology and Biotechnology, Volume 87, Issue 4, pages 481-497)

  F. Grote, R. Ditz, J. Strube

  Article first published online: 25 JAN 2012 | DOI: 10.1002/jctb.2727

• Process development for the extraction of biomolecules Application for downstream processing of proteins in aqueous two-phase systems (Chimica Oggi, Volume 30, Issue 4, July 2012, pages 32-36)

  J. Eggersglüss, S. both, J. Strube

• Biopharmaceutical Production Technology (Wiley-VCH Verlag GmbH & Co. KGaA)

  Editor: G. Subramanian

  Published online: 15 OCT 2012 | Print ISBN: 9783527330294 | Online ISBN: 9783527653096 | DOI: 10.1002/9783527653096

Chapter 12: Modeling and Experimental Model Parameter Determination with Quality by Design for Bioprocesses

C. Helling, J. Strube

Chapter 20: Bioprocess Design and Production Technology for the Future

J. Strube, F. Grote, R. Ditz

• Optimal Integration of Directly Combined Hydrophobic Interaction and Ion-Exchange Chromatography Purification Processes (Chemical Engineering & Technology, Volume 35, Issue 10, pages 1786-1796)

  C. Helling, C. Borrmann, J. Strube

  Article first published online: 25 SEP 2012 | DOI: 10.1002/ceat.201200043

• Prädiktive Modellierung von Trennverfahren (Chemie Ingenieur Technik, Volume 84, Issue 6, page 867)

  J. Strube

  Article first published online: 25 MAY 2012 | DOI: 10.1002/cite.201290051

• Die Produktbereiche der Vielstoffrektifikation (Chemie Ingenieur Technik, Volume 84, Issue 6, pages 868–874)

  Prof. em. Dr.-Ing. Alfons Vogelpohl

  Article first published online: 17 APR 2012 | DOI: 10.1002/cite.201200026

• Separation Technologies 2030 - Are 100 Years of Chromatography Enough? (Chemie Ingenieur Technik, Volume 84, Issue 6, pages 875-879)

  R. Ditz

  Article first published online: 25 MAY 2012 | DOI: 10.1002/cite.201200028

• Pflanzenextraktion: Schlüsseltechnologie zur nachhaltigen Nutzung von Bio-Ressourcen (Chemie Ingenieur Technik, Volume 84, Issue 6, pages 880-882)

  M. Tegtmeier

  Article first published online: 25 APR 2012 | DOI: 10.1002/cite.201200033

• Chemieanlagen der Zukunft - Unikate und/oder Module (Chemie Ingenieur Technik, Volume 84, Issue 6, pages 883-884)

  J. Lang, F. Stenger, R. Schütte

  Article first published online: 20 APR 2012 | DOI: 10.1002/cite.201200036

• Efficient Engineeing by Modularization into Package Units (Chemie Ingenieur Technik, Volume 84, Issue 6, pages 885-891)

  J. Rottke, F. Grote, H. Fröhlich, D. Köster, J. Strube

  Article first published online: 25 APR 2012 | DOI: 10.1002/cite.201200029

• Fundamentals towards a Modular Microstructured Production Plant (Chemie Ingenieur Technik, Volume 84, Issue 6, pages 892-904)

  C. Helling, H. Fröhlich, J. Eggersglüß, J. Strube

  Article first published online: 9 MAY 2012 | DOI: 10.1002/cite.201200031

• Membrane Technology in Bioprocess Science (Chemie Ingenieur Technik, Volume 84, Issue 6, pages 905-917)

  H. Fröhlich, L. Villian, D. Melzner, J. Strube

  Article first published online: 3 MAY 2012 | DOI: 10.1002/cite.201200025

• Characterization of Feed Properties for Conceptual Process Design Involing Complex Mixtures (Chemie Ingenieur Technik, Volume 84, Issue 6, pages 918-931)

  J. P. Josch, J. Strube

  Article first published online: 11 MAY 2012 | DOI: 10.1002/cite.201200030

• Deemulgation of Stabilized Emulsions through the Downstream Processing of Polyunsaturated Fatty Acids (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, page 1180)

  H. Fröhlich, K. Gasser, P. Quast, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250133

• Multi-Stage Extraction in Microprocess Engineering (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, page 1277)

  T. Wellsandt, B. Stanisch, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250160

• Quality-by-Design with Rigorous Process Modeling as Platform Technology of the Future (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, page 1334)

  C. Helling, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250297

• Modell- und Miniplant-basierte Prozessentwicklung einer Proteinaufreinigung über wässrige Zweiphasenextraktion (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, pages 1335-1336)

  J. Eggersglüß, T. Wellsandt, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250143

• Integration of Membrane Unit Operations in Bioprocess Design (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, page 1336)

  H. Fröhlich, C. Helling, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250142

• Modeling and Design of Crystalization Processes of Natural Products (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, page 1349)

  I. Koudous, S. Both, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250163

• Produktionstechnologie für Biologicals (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, page 1350)

  J. Strube, T. Peuker

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250161

• Model-Based Design of Plant-Based Extraction Processes (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, pages 1350-1351)

  S. Both, C. Helling, U. Jenelten, S. Schenk, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250542

• Conceptual Process Design and Optimization by Modeling in Combination with Miniaturized Laboratory Experiments (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, page 1410)

  S. Both, J.P. Josch, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250295

• Material by Design for Liquid Chromatography (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2012 und 30. Jahrestagung der Biotechnologen, Volume 84, Issue 8, page 1416)

  N. Kruse, R. Ditz, J. Strube

  Article first published online: 25 JUL 2012 | DOI: 10.1002/cite.201250568

• Characterization of Feed Properties for Conceptual Process Design Involving Complex Mixtures, Such as Natural Extracts (Food and Nutrition Sciences, Volume 3, pages 836-850)

  J. P. Josch, S. Both, J. Strube

  Article first published online: June 2012 | DOI: 10.4236/fns.2012.36112

 

2011

• New Material Design Strategy for Chromatographic Separation Steps in Bio-Recovery and Downstream Processing (Chemie Ingenieur Technik, Special Issue: Adsorption – Delving into the Molecular Scale, Volume 83, Issue 1-2, pages 113-129)

  E. Ndocko Ndocko, J. P. Josch, R. Ditz, J. Strube

  Article first published online: 30 DEC 2010 | DOI: 10.1002/cite.201000158

• Process Development and Design of Downstream Processes (Chemie Ingenieur Technik, Special Issue: Vom Phänomen auf kleiner Skala zum (Trenn-)-Apparat, Volume 83, Issue 7, pages 1044-1065)

  J. Strube, F. Grote, J. P. Josch, R. Ditz

  Article first published online: 9 JUN 2011 | DOI: 10.1002/cite.201100017

• Integration of Ultrafiltration Unit Operations in Biotechnology Process Design (Chemical Engineering & Technology, Volume 34, Issue 5, pages 673-687)

  F. Grote, H. Fröhlich, J. Strube

  Article first published online: 7 APR 2011 | DOI: 10.1002/ceat.201000484

• Phenomena and Modeling of Hydrophobic Interaction Chromatography (Separation Science and Technology, Volume 46, Issue 8, pages 1289-1305)

  C. Borrmann, C. Helling, M. Lohrmann, S. Sommerfeld, J. Strube

  Article first published online: 19 May 2011 | DOI: 10.1080/01496395.2011.561515

• Method for the Producing of Chemical and Pharmaceutical Products with integrated Multicolumn Chromatography (EP Patent 2336617 A3)

  J. Strube, K. U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen

  First published: 12 September 2012

• Industrial Scale Natural Products Extraction (Wiley-VCH Verlag GmbH & Co. KGaA)

  Editor: H.-J. Bart, S. Pilz

  Published online: 29 APR 2011 | Print ISBN: 9783527325047 | Online ISBN: 9783527635122 | DOI: 10.1002/9783527635122

Chapter 5: Process Engineering and Mini-Plant Technology

J. Strube, W. Bäcker, M. Schulte

• Fluidverfahrenstechnik: Grundlagen, Methodik, Technik, Praxis (Wiley-VCH, Weinheim, 1. Auflage)

  Editor: R. Goedecke

  Published: September 2011 | ISBN: 9783527332700

Chapter 5: Chromatographie

J. Strube, M. Schulte, W. Arlt

 

2010

• A New Approach for Process Development of Plant-Based Extraction Processes (Chemical Engineering & Technology, Volume 33, Issue 3, pages 377-387)

  M. Kaßing, U. Jenelten, J. Schenk, J. Strube

  Article first published online: 9 FEB 2010 | DOI: 10.1002/ceat.200900480

• Integration von hydrophober Interaktions- und Ionenaustauschchromatographie (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, Volume 82, Issue 9, pages 1543-1544)

  C. Helling, C. Borrmann, S. Sommerfeld, M. Lohrmann, J. Strube

  Article first published online: 27 AUG 2010 | DOI: 10.1002/cite.201050398

• Integrierte Prozessentwicklung - Bioproduktion der Zukunft? (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, Volume 82, Issue 9, page 1542)

  F. Grote, R. Ditz, J. Strube

  Article first published online: 27 AUG 2010 | DOI: 10.1002/cite.201050640

• Auslegung von Bioextraktionsprozessen durch Prozessmodellierung in Kombination mit Miniplant-Versuchen am Beispiel der Antikörperaufreinigung (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, Volume 82, Issue 9, page 1569)

  J. E. Eggersglüß, J. Strube

  Article first published online: 27 AUG 2010 | DOI: 10.1002/cite.201050265

• Standardisierte Vorgehensweise zur Verfahrensausledung und -Optimierung von Phytoextraktionsprozessen (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, Volume 82, Issue 9, page 1571)

  R. Kerl, M. Kaßing, U. Jenelten, J. Schenk, J. Strube

  Article first published online: 27 AUG 2010 | DOI: 10.1002/cite.201050622

• Methode zur effizienten Feedcharakterisierung für die Verfahrensentwicklung von komplexen Gemischen am Beispiel von Pflanzenextrakten (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung 2010 und 28. Jahrestagung der Biotechnologen, Volume 82, Issue 9, page 1582)

  J. P. Josch, W. Bäcker, J. Strube

  Article first published online: 27 AUG 2010 | DOI: 10.1002/cite.201050644

 

2009

• Method for the production of chemical and pharmaceutical products with integrated multicolumn chromatography (US Patent 7615159 B2)

  J. Strube, K. U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen

  First published: 10 November 2009

• Status der Fest-Flüssig-Extraktion von Pflanzenmaterial – Stand der Technik und Modellierung (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung und 27. Jahrestagung der Biotechnologen, Volume 81, Issue 8, page 1064)

  M. Kaßing, J. Strube, U. Jenelten, J. Schenk

  Article first published online: 19 AUG 2009 | DOI: 10.1002/cite.200950086

• Methode zur effizienten Feed-Charakterisierung für die Verfahrensentwicklung von komplexen Gemischen am Beispiel von Pflanzenextrakten (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung und 27. Jahrestagung der Biotechnologen, Volume 81, Issue 8, page 1065)

  J. P. Josch, W. Bäcker, J. Strube

  Article first published online: 19 AUG 2009 | DOI: 10.1002/cite.200950391

• Integrierte Bioprozesse - Ökonomie als Innovationstreiber? (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung und 27. Jahrestagung der Biotechnologen, Volume 81, Issue 8, page 1239)

  R. Ditz, F. Grote, J. Strube

  Article first published online: 19 AUG 2009 | DOI: 10.1002/cite.200990067

• Kombination von hydrophober Interaktions- und Ionenaustauschchromatographie (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung und 27. Jahrestagung der Biotechnologen, Volume 81, Issue 8, pages 1239-1240)

  C. Borrmann, S. Sommerfeld, M. Lohrmann, J. Strube

  Article first published online: 19 AUG 2009 | DOI: 10.1002/cite.200950067

• Downstream of Downstream Processing - Integrated Bioprocess Development from Upstream to Downstream (Chemie Ingenieur Technik, Special Issue: ProcessNet-Jahrestagung und 27. Jahrestagung der Biotechnologen, Volume 81, Issue 8, pages 1276-1277)

  F. Grote, R. Ditz, J. Strube

  Article first published online: 19 AUG 2009 | DOI: 10.1002/cite.200950116

 

2008

• Process Design Method for Manufacturing of Natural Compounds and Related Molecules (Separation Science and Technology, Volume 43, Issue 3, pages 642-670)

  E. Ndocko, W. Bäcker, J. Strube

  Article first published online: February 2008 | DOI: 10.1080/01496390701812525

• Method for the Production of Chemical and Pharmaceutical Products with integrated Multicolumn Chromatography (US Patent 20080135483 A1)

  J. Strube, K. U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen

  First published: 10 June 2008

• Design and Optimization of a Hybrid Distillation/Melt Crystallization Process (AIChE Journal, Volume 54, Issue 11, pages 2925-2942)

  M. B. Franke, N. Nowotny, E. Ndocko Ndocko, A. Gorak, J. Strube

  Article first published online: 6 OCT 2008 | DOI: 10.1002/aic.11605

• Entwurf und Auslegung von Phytoextraktionsprozessen - Standardapparatur und Modellierung (Chemie Ingenieur Technik, Special Issue: ProcessNet Jahrestagung 2008, Volume 80, Issue 9, page 1301)

  M. Kaßing, F. Grote, J. Strube

  Article first published online: 12 SEP 2008 | DOI: 10.1002/cite.200750487

• Integrierte Bioprozessentwicklung - Upstream, Downstream und "Downstream of Downstream" (Chemie Ingenieur Technik, Special Issue: ProcessNet Jahrestagung 2008, Volume 80, Issue 9, pages 1312-1313

  F. Grote, R. Ditz, J. Strube

  Article first published online: 12 SEP 2008 | DOI: 10.1002/cite.200750767

 

2007

• Liquid Distributor and Liquid Collector for Chromatography Columns (US 20070246428 A1)

  GH. Klepp, S. Böcker, J. Strube, H. Kansy, H. Schmale, H. Schmale

• Bioseparation and Bioprocessing A Handbook Volume 1 and 2 (Wiley-VCH, Weinheim, 2007 )

  Editor: G. Subramanian

  ISBN: 978-3-527-31585-7
  • Chapter 3:  Process Developemnt and optimization for Biotechnology Production – Monoclonal Antibodies

            J. Strube, S. Sommerfeld, M. Lohrmann (2007)

  • Chapter 8: Continuous Chromatography in the Downstream Processing of Products of Biotechnological and Natural Origin

    M. Schulte, K. Wekenborg, J. Strube (2007)

• Bioseparation and Bioprocessing: Biochromatogrpahy, Membrane Separations, Modeling, Validation (WILEY-VCH Verlag GmbH)

  Editor: G. Subramanian

  Published online: 24 APR 2008 | Print ISBN: 9783527288762 | Online ISBN: 9783527619641 | DOI: 10.1002/9783527619641

Chapter: Continuous Bio Chromatography

K. Wekenborg, M. Schulte, J. Strube

Chapter: Process Development and Optimization Methods in Biorecovery

K. Wekenborg, M. Schulte, J. Strube

• Method for the production of chemical and pharmaceutical products with integrated multicolumn chromatography (EP Patent 1753517 A2)

  J. Strube, K.U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen

  First published: 21 February 2007

• Liquid distributor and liquid collector for chromatography columns (EP Patent 1792174 A1

  G. H. Klepp, S. Böcker, J. Strube, H. Kansy, H. Schmale

  First published: 6 June 2007

 

2006

• Fluid Separation Technology (John Wiley&Sons)

  Editor: R. Goedecke

Chapter: Technical Chromatography

W. Arlt, M. Schulte, J. Strube

• Dynamic Simulation of a Simulated-Moving-Bed Chromatographic Reactor for the Inversion of Sucrose (Starch - Stärke, Volume 48, Issue 11-12, pages 452-457)

  M. Meurer, U. Altenhöner, J. Strube, A. Untiedt, H. Schmidt-Traub

  Article first published online: 26 OCT 2006 | DOI: 10.1002/star.19960481113

• Integrated Downstream Process Design in Biorecovery - The White Knight to Slay the Cost Dragon? (Chemie Ingenieur Technik, Special Issue: GVC/DECHEMA-Jahrestagungen 2006 mit 24. DECHEMA-Jahrestagung der Biotechnologen, Volume 78, Issue 9, page 1199

  J. Strube, R. Ditz

  Article first published online: 6 SEP 2006 | DOI: 10.1002/cite.200650485

• Liquid distributor and liquid collector for chromatography columns (WO Patent 2006027118 A1)

  G.H. Klepp, S. Böcker, J. Strube, H. Kansy, H. Schmale

  First published: 16 March 2006

• Flüssigkeitsverteiler und Flüssigkeitssammler für Chromatographiesäulen (DE Patent 102004043362 A1)

  G.H. Klepp, S. Böcker, J. Strube, H. Schmale, H. Kansy

  First published: 9 March 2006

 

2005

• Generic Method for Systematic Phase Selection and Method Development of Biochromatographic Processes - Part 1: Selection of a Suitable Cation-Exchanger for the Purification of a Pharmaceutical Protein (Journal of Chromatography A, Volume 1092, Issue 1, Pages 89-100)

  M. Lohrmann, M. Schulte, J. Strube

  Article first published online: 15 June 2005 | DOI: 10.1016/j.chroma.2005.05.067

• Challenges in Biotechnology Production - Generic Processes and Process Development for Monoclonal Antibodies (Chemical Engineering and Processing, Volume 44, Issue 10, pages 1123-1137)

  S. Sommerfeld, J. Strube

  Article first published online: October 2005 | DOI: 10.1016/j.cep.2005.03.006

• Design and Optimization of Layer Crystallization Processes (Computer Aided Chemical Engineering, Volume 20, pages 871-876)

  C. Wallert, M. Marquart, J.T. Leu, J. Strube

  Article first published online: 22 June 2007 | DOI: 10.1016/S1570-7946(05)80267-6

• Method for the Production of Chemical and Pharmaceutical Products with integrated Multicolumn Chromatography (WO Patent 2005,113,101)

  J. Strube, K.U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen

  First published: 17 July 2008

• Continuous Method for Separating Substances according to Molecular Size (EP Patent 1,140,316)

  L. Britsch, M. Schulte, J. Strube

• Liquid Distributor and Liquid Collector for Chromatography Columns (US Patent 20070246428 A1)

  G.H. Klepp, S. Böcker, J. Strube, H. Kansy, H. Schmale

  First published: 25 October 2007

• Lösungsansätze zur systematischen Prozessentwicklung und Auslegung der Aufarbeitung von Biopharmazeutika (Chemie Ingenieur Technik, Special Issue: GVC/DECHEMA-Jahrestagungen, Volume 77, Issue 8, pages 1191-1192)

  S. Sommerfeld, J. Strube, M. Schulte, R. Ditz

  Article first published online: 10 AUG 2005 | DOI: 10.1002/cite.200590356

 

2004

• 56. Dynamische Simulation des Chromatographieprozesses mit scheinbarem Gegenstrom (Chemie Ingenieur Technik, Volume 66, Issue 9, pages 1195-1196)

  H. Schmidt-Traub, J. Strube, S. Michel

  Article first published online: 2 FEB 2004 | DOI: 10.1002/cite.330660957

• Dynamische Simulation des kontinuierlichen SMB (Simulated-Moving-Bed)-Chromatographie-Prozesses (Chemie Ingenieur Technik, Volume 67, Issue 3, pages 323-326)

  H. Schmidt-Traub, J. Strube, H.-I. Paul, S. Michel

  Article first published online: 2 FEB 2004 | DOI: 10.1002/cite.330670311

• Auslegung und Optimierung von hybriden Trennverfahren (Chemie Ingenieur Technik, Volume 76, Issue 3, pages 199-210)

  M. Franke, A. Górak, J. Strube

  Article first published online: 23 FEB 2004 | DOI: 10.1002/cite.200406150

• Hybride Trennprozesse - Forschungsbedard oder industriell gelöst? (Chemie Ingenieur Technik, Volume 76, Issue 9, page 1344)

  J. Strube, W. Bäcker, G. Olf, E. Dikow, A. Gorak, M. Franke

  Article first published online: 1 OCT 2004 | DOI: 10.1002/cite.200490244

• Generische Methode zur Phasenauswahl und Methodenoptimierung in der Biochromatographie (Chemie Ingenieur Technik, Volume 76, Issue 9, pages 1414-1415)

  M. Lohrmann, M. Schulte, J. Strube

  Article first published online: 1 OCT 2004 | DOI: 10.1002/cite.200490312

 

2003

• Hybrid Processes: Design Method for Optimal Coupling of Chromatography and Crystallization Units (Separation Science and Technology, Volume 38, Issue 14, pages 3353-3383)

  G. Ströhlein, M. Schulte, J. Strube

  Article first published online: January 2003 | DOI: 10.1081/SS-120023404

• Modelling gradient elution of bioactive multicomponent systems in non-linear ion-exchange chromatography (Journal of Chromatography A, Volume 1006, Issues 1-2, pages 101-120)

  A. Wiesel, H. Schmidt-Traub, J. Lenz, J. Strube

  Article first published online: 17 May 2003 | DOI: 10.1016/S0021-9673(03)00554-5

• Continuous Method for Separating Substances According to Molecular Size (US Patent 6.511.512)

  L. Britsch, M. Schulte, J. Strube

  First published: 22 April 2003

• Thermische Trennverfahren als Schlüsseltechnologie in den Life-Sciences (Chemie Ingenieur Technik, Volume 75, Issue 8, pages 1071-1072)

  J. Strube, M. Schulte

  Article first published online: 26 AUG 2003 | DOI: 10.1002/cite.200390340

• Phyto-Extrakte: Verfahrenstechnischer Bedarf für Produkte und Prozesse (Chemie Ingenieur Technik, Volume 75, Issue 8, page 1077)

  R. Stockfleth, R. Goedecke, W. Johannisbauer, W. Bäcker, J. Strube

  Article first published online: 26 AUG 2003 | DOI: 10.1002/cite.200390246

• Auslegung und Optimierung von hybriden Trennprozessen zur Isomerentrennung (Chemie Ingenieur Technik, Volume 75, Issue 8, pages 1162-1163)

  M. Franke, A. Górak, J. Strube

  Article first published online: 26 AUG 2003 | DOI: 10.1002/cite.200390407

• Generische Methode zur Phasenauswahl und Methodenoptimierung in der Biochromatographie (Chemie Ingenieur Technik, Volume 75, Issue 8, page 1169)

  M. Lohrmann, M. Schulte, J. Strube

  Article first published online: 26 AUG 2003 | DOI: 10.1002/cite.200390414

 

2002

• Process development of product recovery and solvent recycling steps of chromatographic separation steps (Chemical Engineering Journal, Volume 85, Issues 2-3, pages 273-288)

  J. Strube, R. Gärtner, M. Schulte

Article first published online: 13 January 2002 | DOI: 10.1016/S1385-8947(01)00171-1

• Auslegung von Extraktionsverfahren im Prozessverbund (Chemie Ingenieur Technik, Volume 74, Issue 5, page 594)

  J. Strube, J. Leistner, M. Franke, A. Gorak, W. Bäcker

• Extraktion als Mittel zur Abwasseraufarbeitung (Chemie Ingenieur Technik, Volume 74, Issue 5, page 606)

  J. Leistner, A. Gorak, W. Bäcker, J. Strube

  Article first published online: 24 MAY 2002 | DOI: 10.1002/1522-2640(200205)74:5<606::AID-CITE606>3.0.CO;2-7

• Modellierung der Trennung von Mehrkomponentensystemen mittels Gradientenelution in der präparativen Ionenaustausch-Chromatographie (Chemie Ingenieur Technik, Volume 74, Issue 5, page 677)

  A. Wiesel, H. Schmidt-Traub, J. Lenz, J. Strube

  Article first published online: 24 MAY 2002 | DOI: 10.1002/1522-2640(200205)74:5<677::AID-CITE677>3.0.CO;2-C

 

2001

• Preparative enantioseparation by simulated moving bed chromatography (Journal of Chromatography A, Volume 906, Issues 1-2, pages 399-416

  M. Schulte, J. Strube

  Article first published online: 10 January 2001 | DOI: 10.1016/S0021-9673(00)00956-0

 

2000

• Continuous preparative liquid chromatography in the downstrem processing of biotechnological products (Acta Biotechnologica, Volume 20, Issue 1, pages 3-15

  M. Schulte, L. Britsch, J. Strube

  Article first published online: 2 FEB 2004 | DOI: 10.1002/abio.370200102

• Technische Chromatographie: Auslegung, Optimierung, Betrieb und Wirtschaftlichkeit (Shaker Verlag, Aachen, Habilitation, Universität Dortmund)

  J. Strube

  ISBN: 978-3-8265-6897-8

• Continuous Method for Separating Substances According to Molecular Size (WO Patent 2000,037,156)

  L. Britsch, M. Schulte, J. Strube

  First published: 29 June 2000

 

1999

• Design, Optimization and Operation of SMB Chromatography in the Production of Enantiomerically Pure Pharmaceuticals (Chirality, Volume 11, Issue 5-6, pages 440-450)

  J. Strube, A. Jupke, A, Epping, H. Schmidt-Traub, M. Schulte, R. Devant

  Article first published online: 11 MAY 1999 | DOI: 10.1002/(SICI)1520-636X(1999)11:5/6<440::AID-CHIR15>3.0.CO;2-K

 

1998

• Modeling of simulated moving bed chromatographic processes with regard to process control design (Computers & Chemical Engineering, Volume 22, Supplement 1, Pages S855-S858)

  G. Dünnebier, I. Weirich, K.U. Klatt, S. Engell, J. Strube, H. Schmidt-Traub

  Article first published online: 13 September 2000 | DOI: 10.1016/S0098-1354(98)00165-3

• Dynamic simulation of simulated-moving-bed chromatographic processes (Computers & Chemical Engineering, Volume 22, Issue 9, Pages 1309-1317)

  J. Strube, H. Schmidt-Traub

  Article first published online: 28 June 1999 | DOI: 10.1016/S0098-1354(98)00015-5

• Comparison of Batch Elution and Continuous Simulated Moving Bed Chromatography (Organic Process Research & Development, Volume 2, Issue 5, pages 305-319)

  J. Strube, S. Haumreißer, H. Schmidt-Traub, M. Schulte, R. Ditz

  Article first published online: 18 July 1998 | DOI: 10.1021/op980019a

• 51. Modellierung chromatographischer Trennprozesse: Ein Überblick unter besonderer Berücksichtigung der Prozeßführung und On-line-Optimierung (Chemie Ingenieur Technik, Volume 70, Issue 9, pages 1099-1100

  K.U. Klatt, G. Dünnebier, S. Engell, J. Strube, H. Schmidt-Traub

  Article first published online: 2 MAR 2004 | DOI: 10.1002/cite.330700955

• Auslegung, Betrieb und ökonomische Betrachtung chromatographischer Trennprozesse (Chemie Ingenieur Technik, Volume 70, Issue 10, pages 1271-1279)

  J. Strube, H. Schmidt-Traub, M. Schulte

  Article first published online: 2 MAR 2004 | DOI: 10.1002/cite.330701006

• Simulated moving bed chromatography technology in pharmaceutical new product development-it's impact on the industry's race to the market. (Current Opinion in Drug Discovery & Development, Volume 1, Issue 3, pages 264-274)

  R. Ditz, M. Schulte, J. Strube

  PMID: 19649801 [PubMed]

• Design and Optimization of Chromatographic Processes in Production Scale (AIChE Symposium Series 94, No. 320, pages 440-450

  J. Strube, H. Schmidt-Traub, M. Schulte, R. Ditz

 

 

1997

• Dynamic simulation of simulated moving bed chromatographic reactors Journal of Chromatography A, Volume 769, Issue 1, pages 71-79)

  M. Meurer, U. Altenhöner, J. Strube, H. Schmidt-Traub

  Article first published online: 27 May 1998 | DOI: 10.1016/S0021-9673(96)00980-6

• Parameter estimation for the simulation of liquid chromatography (Journal of Chromatography A, Volume 769, Issue 1, pages 59–69)

  U. Altenhöner, M. Meurer, J. Strube, H. Schmidt-Traub

  Article first published online: 27 May 1998 | DOI: 10.1016/S0021-9673(97)00173-8

• Dynamic simulation of simulated moving-bed chromatographic processes for the optimization of chiral separations (Journal of Chromatography A, Volume 769, Issue 1, pages 81–92)

  J. Strube, U. Altenhöner, M. Meurer, M. Schulte, H. Schmidt-Traub

  Article first published online: 27 May 1998 | DOI:10.1016/S0021-9673(97)00236-7

• Experimenteller Vergleich verschiedener thermischer Desorptionsverfahren zur Lösungsmittelrückgewinnung (Chemie Ingenieur Technik, Volume 69, Issue 1-2, pages 132-134)

  D. Bathen, J. Strube, H. Schmidt-Traub

  Article first published online: 2 FEB 2004 | DOI: 10.1002/cite.330690125

• Optimierung kontinuierlicher Simulated Moving Bed-Chromatographie-Prozesse durch dynamische Simulation (Chemie Ingenieur Technik, Volume 69, Issue 3, pages 328-331)

  J. Strube, U. Altenhöner, M. Meurer, H. Schmidt-Traub

  Article first published online: 2 FEB 2004 | DOI: 10.1002/cite.330690310

• Auslegung und Betrieb chromatographischer Trennprozesse (Chemie Ingenieur Technik, Volume 69, Issue 9, page 1219)

  J. Strube, U. Altenhöner, M. Meurer, H. Schmidt-Traub, M.Schulte, R. Ditz

  Article first published online: 2 FEB 2004 | DOI: 10.1002/cite.330690903

• Entwurf und Auslegung kontinuierlicher Simulated-Moving-Bed Chromatographie-Reaktoren (Chemie Ingenieur Technik, Volume 69, Issue 11, pages 1627-1631)

  M. Meurer, U. Altenhöner, J. Strube, H. Schmidt-Traub

  Article first published online: 2 FEB 2004 | DOI: 10.1002/cite.330691117

 

 

1996

• Simulation und Optimierung kontinuierlicher Simulated Moving Bed (SMB)-Chromatographie-Prozesse (Dissertation 4/1996)

  J.Strube

• Dynamic Simulation of Simulated-Moving-Bed Chromatographic Processes (Computers & Chemical Engineering, Volume 20, Supplement 1, Pages S641-S646)

  J. Strube, H. Schmidt-Traub

  DOI: 10.1016/0098-1354(96)00116-0

 

 

1995

 

• Dynamische Simulation des kontinuierlichen SMB (Simulated Moving Bed)-Chromatographie-Prozesses (Chemie Ingenieur Technik, Volume 67, Issue 3, pages 323-326)

  J. Strube, S. Michel, H.-I. Paul, H. Schmidt-Traub

  Article first published online: 2 FEB 2004 | DOI: 10.1002/cite.330670311

 

1994

 

• Kontinuierliche Gegenstrom-Chromatographie-Verfahren mit Desorption und/oder Regeneration durch Mikrowellenenergie (Patent-Antrag P 44 14 599.3-43)

  J. Strube, H. Schmidt-Traub

• Dynamische Simulation des Chromatographie-Prozesses mit scheinbarem Gegenstrom (Chemie Ingenieur Technik, Volume 66, pages 1193-1193)

  J. Strube, H. Schmidt-Traub