Training Courses

Dechema Traning Course 2018: Process Chromatography

 

PDA Kurs 2018: DSP- Purification of Biomolecules

In manufacturing of bio-molecules often 50-90 % of the Cost of Goods (COG) are caused by Downstream Processing (DSP). In process development separation processes must be proposed in an efficient sequence based on physico-chemical properties of target molecules, contaminants, side components and impurities to increase yield/recovery.

 

In this course the design of unit operations like ultrafiltration / diafiltration (UF/DF), ion exchange- and affinity-membranes as well as affinity, ion exchange (IEX), immobilized metal affinity (IMAC), size exclusion (SEC), hydrophobic interaction (HIC) and reversed phase chromatography is presented and explained. These are established key-technologies which are highly efficient and broadly used in manufacturing. Additionally, protein refolding, extraction and precipitation/crystallization are discussed. Moreover, methods for virus inactivation and clearance are explained.

 

Termin: February 25.-28, 2018

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Dechema VBU Kurs 2018: CPB - Continuous Bioprocessing of Biomolecules

For synthetic APIs, increasing attempts to move from traditional batch to continuous manufacturing are ongoing. Advantages are in particular higher product safety by enhanced process robustness, smaller foot print of the plants, lower cleaning costs and down-times due to dedicated modular and flexible plants.

 

For the production of biopharmaceuticals, e.g. monoclonal antibodies, fermentation is already more often used in a continuous perfusion mode than is known to the public. Therefore, it is only consistent to apply continuous process concepts also for downstream processing operations. In manufacturing of biomolecules these concepts have so far only been applied for high-volume bulk or fine chemicals. However, with the upcoming cost issues in the manufacturing of biotherapeutics by low cost biogeneric manufacturers and stratified medicine scenarios, first approaches to industrialize continuous manufacturing for biologics like amino acids, peptides, proteins and monoclonal antibodies and fragments, are under investigation

 

The course will describe the design and scheduling of unit operations in continuous manufacturing processes in contrast to classical batch operations and aims at providing viable decision criteria.

 

Termin: February 27.- March 01, 2018

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Registration

 

FAH Course 2017: Phytoextraction

 

Dechema VBU Kurs 2016: DSP- Purification of Biomolecules

Further Informations

 

Dechema VBU Kurs 2016: CPB - Continuous Bioprocessing of Biomolecules

Further Informations

 

Dechema Traning Course 2015: Process Chromatography

Further Information

Dechema Traning Course 2014: Phytoextraction

Further Information

Dechema Traning Course 2013: DSP of Biomolecules

 

Dechema Traning Course 2012: Process Chromatography

 

Dechema Traning Course 2011: Phytoextraction

 

Dechema VBU Traning Course 2010: DSP of Biomolecules

 

Dechema VBU Traning Course 2008: DSP of Biomolecules

Pictures from the course

 

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