Institute for Separation and Process Technology > Research > Material design > Integration of material design and process development methods for downstream processing of recombinant proteins and MABS

Integration of material design and process development methods for downstream processing of recombinant proteins and MABS

This research project on material design includes the development of novel methods for the targeted production of inorganic and organic auxiliaris for selective thermal separation technology as the medium of extraction, membranes and adsorbents. They are characterized with regard to material- and performance parameters and their use in thermal unit operations and the experimental determination of phase equilibria, kinetic parameters and fluid dynamic parameters. This along with modeling and simulation of unit operations in the overall as well as state-of-the-art processes of thermal separation technology material concepts with the objective of process intensification are the main focus of this research.

     

The downstream processing of biomolecules, such as recombinant protein, and antibody purification as well as separation of isomers and enantiomers from fine chemicals and pharmaceutical industries are being investigated. The aim is the modeling the separation in conventional and monolithic media, taking into account the influence of mass transport processes and the description and optimization of the experimental comparison of monoliths and particles.

 

Contact person: Dipl.-Ing. Christoph Helling

 

 

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