Staff Overview

Jochen, Strube

Contact

Institutsleiter
Leibnizstraße 15
D-38678 Clausthal-Zellerfeld
Germany
Room: 304
05323-72-2200
05323-72-3570
  • Anlagen- und Prozeßtechnik, Thermische Verfahrenstechnik, Bioverfahrenstechnik
  • Modellierung und Simulation verfahrenstechnischer Systeme, Dynamische Simulation mit SPEEDUPTM/ gPROMS/ AspenCustomModelerTM, Stationäre Simulation mit ASPENPLUSTM
  • Pharmazeutische Verfahrenstechnik/Life Science Engineering
  • DECHEMA e.V. Weiterbildungskurse ”Auslegung und Betrieb chromatographischer Trennprozesse”, „Process Chromatography“ und „Downstream Processing“
  • Betreuung von ca. 110 Studien- und Diplomarbeiten sowie ca. 12 Promotionen
  •  ca. 7 Patente, ca. 40 Veröffentlichungen sowie ca. 120 nationale und internationale Vorträge
  • Mitglied Scientific Committee SPICA und FOA, Dechema e.V. Fachausschuss Adsorption Leitung Chromatographie, Arbeitskreisvorsitzender Phytoextrakte

1994

  • Patent-Antrag P 44 14 599.3-43
    Kontinuierliche Gegenstrom-Chromatographie-Verfahren mit Desorption und/oder Regeneration durch Mikrowellenenergie
    J. Strube, H. Schmidt-Traub
  • Chem.-Ing.-Tech. 66 (1994), pp. 1193-1193
    Dynamische Simulation des Chromatographie-Prozesses mit scheinbarem Gegenstrom
    J. Strube, H. Schmidt-Traub

1995

  • Chem.-Ing.-Tech. 67 (1995) Nr. 3, S. 323-326
    Dynamische Simulation des kontinuierlichen SMB (Simulated-Moving-Bed)-Chromatographie-Prozesses
    J. Strube, S. Michel, H.-I. Paul, H. Schmidt-Traub

1996

  • Dissertation 4/1996 Universität Dortmund
    Simulation und Optimierung kontinuierlicher Simulated Moving Bed (SMB)-Chromatographie-Prozesse
    J. Strube
  • Comp. chem. Engng. Vol. 20, Suppl., pp. S641-646, 1996
    Dynamic Simulation of Simulated-Moving-Bed Chromatographic Processes
    J. Strube, H. Schmidt-Traub

1997

  • J. Chromatogr. A, 769 (1997) 71-79
    Dynamic Simulation of Simulated Moving Bed Chromatographic Reactors
    M. Meurer, U. Altenhöner, J. Strube, H. Schmidt-Traub
  • J. Chromatogr. A, 769 (1997) 59-69
    Parameter-Estimation for the Simulation of Fluid-Chromatography
    U. Altenhöner, M. Meurer, J. Strube, H. Schmidt-Traub
  • J. Chromatogr. A, 769 (1997) 81-92
    Dynamic Simulation of the Simulated Moving Bed Chromatographic Process for the Optimization of Chiral Separations
    J. Strube, U. Altenhöner, M. Meurer, M. Schulte, H. Schmidt-Traub
  • Chem.-Ing.-Tech 69 (1997) Nr. 1-2, pp. 132-134
    Experimenteller Vergleich verschiedener thermischer Desorptions-verfahren zur Lösungsmittelrückgewinnung
    D. Bathen, J. Strube, H. Schmidt-Traub
  • Chem.-Ing.-Tech 69 (1997) Nr. 3, pp. 328-331
    Optimierung kontinuierlicher Simulated Moving Bed-Chromatographie-Prozesse durch dynamische Simulation
    J. Strube, U. Altenhöner, M. Meurer, H. Schmidt-Traub
  • Chem.-Ing.-Tech 69 (1997) Nr. 9, pp. 1219-1219
    Auslegung und Betrieb chromatographischer Trennprozesse
    J. Strube, U. Altenhöner, M. Meurer, H. Schmidt-Traub, M.Schulte, R. Ditz
  • Chem.-Ing.-Tech. 69 (1997), Nr. 11, pp. 1627-1631

    Entwurf und Auslegung kontinuierlicher Simulated Moving Bed Chromatographie-Reaktoren
    M. Meurer, U. Altenhöner, J. Strube, H. Schmidt-Traub

1998

  • Comp. chem. Engng. 22, (1998), pp. 855-858
    Modeling of Simulated Moving Bed Chromatographic Processes with regard to Process Control Design
    G. Dünnebier, I. Weirich, K.U. Klatt, S. Engell, J. Strube, H. Schmidt-Traub
  • Comp. chem. Engng. 22 (1998)  No. 9, pp. 1309-1317
    Dynamic Simulation of Simulated Moving Bed (SMB-)Chromatographic Processes
    J. Strube, H. Schmidt-Traub
  • Organic Process Research & Development 1 (1998), pp. 305-319
    Comparison of Batch Elution and Continuous Simulated Moving Bed Chromatography
    J. Strube, S. Haumreißer, H. Schmidt-Traub, M. Schulte, R. Ditz
  • Chem.-Ing.-Tech. 70 (1998), Nr. 9, pp. 1099-1100
    51. Modellierung chromatograpischer Trennprozesse: Ein Überblick unter besonderer Berücksichtigung der Prozessführung und Online-Optimierung
    K.U. Klatt, G. Dünnebier, S. Engell, J. Strube, H. Schmidt-Traub
  • Chem.-Ing.-Tech. 70 (1998), Nr. 10, pp. 1271-1279
    Auslegung, Betrieb und ökonomische Betrachtung chromatographischer Trennprozesse
    J. Strube, H. Schmidt-Traub, M. Schulte
  • Current Opinion in Drug Discovery & Development (1998), pp. 264-274
    Simulated Moving Bed Chromatography Technology in Pharmaceutical New Product Development - It's Impact on the Industry's Race to the Market.
    R. Ditz, M. Schulte, J. Strube
  • AIChE Symposium Series 94 (1998) No. 320, pp. 440-450
    Design and Optimization of Chromatographic Processes in Production Scale
    J. Strube, H. Schmidt-Traub, M. Schulte, R. Ditz

1999

  • Chirality 11 (1999) No. 2, pp. 440-450
    Design, Optimization and Operation of SMB Chromatography in the Production of Enantiomerically Pure Pharmaceuticals
    J. Strube, A. Jupke, A, Epping, H. Schmidt-Traub, M. Schulte, R. Devant
  • EP Patent 1140316 B1
    Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgrösse
    L. Britsch, M. Schulte, J. Strube

2000

  • Acta Biotechnologica 20 (2000) No. 1, pp. 3-15
    Review: Continuous preparative liquid chromatography in the downstream processing of biotechnological products
    M. Schulte, L. Britsch, J. Strube
  • Shaker Verlag, Aachen
    Habilitation, Universität Dortmund, FB CT, Mai 1999 Technische Chromatographie - Auslegung, Optimierung, Betrieb und Wirtschaftlichkeit
    J. Strube
  • WO Patent 2000,037,156
    Continuous Method for Separating Substances According to Molecular Size
    L. Britsch, M. Schulte, J. Strube

2001

  • Journal of Chromatography A 906 (2001), pp. 399-416
    Review: Preparative Enantioseparation by Simulated Moving Bed (SMB-) Chromatography
    M. Schulte, J. Strube

2002

  • Chem. Eng. J. 85 (2002) pp. 273-288
    Process development of product recovery and solvent recycling steps of chromatographic separation steps
    J. Strube, R. Gärtner, M. Schulte
  • Chem.-Ing.-Tech. 74 (2002) Nr. 5, pp. 594-594
    Auslegung von Extraktionsverfahren im Prozessverbund
    J. Strube, J. Leistner, M. Franke, A. Gorak, W. Bäcker
  • Chem.-Ing.-Tech. 74 (2002) Nr. 5, pp. 606-606
    Extraktion als Mittel zur Abwasseraufbereitung
    J. Leistner, A. Gorak, W. Bäcker, J. Strube
  • Chem.-Ing.-Tech. 74 (2002) Nr. 5, pp. 677-677

    Modellierung der Trennung von Mehrkomponentensystemen mittels Gradientenelution in der präparativen Ionenaustausch-Chromatographie
    A. Wiesel, H. Schmidt-Traub, J. Lenz, J. Strube

2003

  • Separation Science and Technology 38 (2003) No. 14, pp. 3353-3383
    Hybrid Processes: Design Method for optimal Coupling of Chromatography and Crystallization Units
    G. Ströhlein, M. Schulte, J. Strube
  • Journal of Chromatography A, 1006 (2003) pp. 101-120
    Modeling Gradient Elution of bioactive Multicomponent Systems in nonlinear Ion Exchange Chromatography
    Wiesel, H. Schmidt-Traub, J. Lenz, J. Strube
  • US Patent 6.511.512
    Continuous Method for Separating Substances According to Molecular Size
    L. Britsch, M. Schulte, J. Strube
  • Chem.-Ing.-Tech. 75 (2003) Nr. 8, pp. 1071-1072
    Thermische Trennverfahren als Schlüsseltechnologie in den Life-Sciences
    J. Strube, M. Schulte
  • Chem.-Ing.-Tech. 75 (2003) Nr. 8, pp. 1077-1077
    Phyto-Extrakte: Verfahrenstechnischer Bedarf für Produkte und Prozesse
    R. Stockfleth, R. Goedecke, W. Johannisbauer, W. Bäcker, J. Strube
  • Chem.-Ing.-Tech. 75 (2003) Nr. 8, pp. 1162-1163
    Auslegung und Optimierung von hybriden Trennprozessen zur Isomerentrennung
    M. Franke, A. Gorak, J. Strube
  • Chem.-Ing.-Tech. 75 (2003) Nr. 8, pp. 1169-1169
    Generische Methode zur Phasenauswahl und Methodenoptimierung in der Biochromatographie
    M. Lohrmann, M. Schulte, J. Strube

2004

  • Chem.-Ing.-Tech. 66 (2004) Nr. 9, pp. 1195-1196
    56. Dynamische Simulation des Chromatographieprozesses mit scheinbarem Gegenstrom
    H. Schmidt-Traub, J. Strube, S. Michel
  • Chem.-Ing.-Tech. 67 (2004) Nr. 3, pp. 323-326
    Dynamische Simulation des kontinuierlichen SMB (Simulated-Moving-Bed)-Chromatographie-Prozesses
    H. Schmidt-Traub, J. Strube, H.-I. Paul, S. Michel
  • Chem.-Ing.-Tech. 76 (2004) Nr. 3, pp. 199-210
    Auslegung und Optimierung von hybriden Trennverfahren
    M. Franke, A. Górak, J. Strube
  • Chem.-Ing.-Tech. 76 (2004) Nr. 9, pp. 1344-1344
    Hybride Trennprozesse - Forschungsbedard oder industriell gelöst?
    J. Strube, W. Bäcker, G. Olf, E. Dikow, A. Gorak, M. Franke
  • Chem.-Ing.-Tech. 76 (2004) Nr. 9, pp. 1414-1415
    Generische Methode zur Phasenauswahl und Methodenoptimierung in der Biochromatographie
    M. Lohrmann, M. Schulte, J. Strube

2005

  • Journal of Chromatography A (2005), pp. 89-100
    Generic Method for Systematic Phase Selection and Method Development of Biochromatographic Processes - Part 1: Selection of a Suitable Cation-Exchanger for the Purification of a Pharmaceutical Protein
    M. Lohrmann, M. Schulte, J. Strube
  • Chemical Engineering and Processing 44 (2005), pp. 1123-1137
    Challenges in Biotechnology Production - Generic Processes and Process Development for Monoclonal Antibodies
    S. Sommerfeld, J. Strube
  • Comp. Chem. Engng. 20 (2005) pp. 871-876

    Design and Optimization of Layer Crystallization Processes
    C. Wallert, M. Marquart, J.T. Leu, J. Strube
  • WO Patent 2005,113,101

    Method for the Production of Chemical and Pharmaceutical Products with integrated Multicolumn Chromatography
    J. Strube, K.U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen
  • EP Patent 1,140,316

    Continuous Method for Separating Substances according to Molecular Size
    L. Britsch, M. Schulte, J. Strube
  • US Patent App. 11/574,849

    Liquid Distributor and Liquid Collector for Chromatography Columns
    G.H. Klepp, S. Böcker, J. Strube, H. Kansy, H. Schmale
  • Chem.-Ing.-Tech. 77 (2005) Nr. 8, pp. 1191-1192

    Lösungsansätze zur systematischen Prozessentwicklung und Auslegung der Aufarbeitung von Biopharmazeutika
    S. Sommerfeld, J. Strube, M. Schulte, R. Ditz

  • EP Patent 2336617 B1

    Modular Valve System and its use in a method for producing chemical and pharmaceutical products with integrated multi-column chromatography
    J. Strube, K.U. Klatt, G. Noeth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn

2006

  • John Wiley&Sons, Book: Fluid Separation Technology, Editor: R. Goedecke

    Technical Chromatography
    W. Arlt, M. Schulte, J. Strube

  • Starch-Stärke 48 (2006), pp. 452-457
    Dynamic Simulation of a Simulated-Moving-Bed Chromatography Reactor for the Inversion of Sucrose
    M. Meurer, U. Altenhöner, J. Strube, A. Untiedt, H. Schmidt-Traub
  • Chem.-Ing.-Tech. 78 (2005) Nr. 9, pp. 1199-1199

    Integrated Downstream Process Design in Biorecovery - The White Knight to Slay the Cost Dragon?
    J. Strube, R. Ditz
  • WO Patent 2,006,027,118

    Liquid Distributor and Liquid Collector for Chromatography Columns
    G.H. Klepp, S. Böcker, J. Strube, H. Kansy, H. Schmale
  •  DE Patent 102,004,043,362

    Flüssigkeitsverteiler und Flüssigkeitssammler für Chromatographiesäulen
    G.H. Klepp, S. Böcker, J. Strube, H. Schmale, H. Kansy

2007

  • John Wiley&Sons, Book: Bioseparation and Bioprocessing, Editor: G. Subramanian
    Continuous Bio Chromatography
    K. Wekenborg, M. Schulte, J. Strube
    Process Development and Optimization Methods in Biorecovery
    J. Strube, S. Sommerfeld, M. Lohrmann
  • EP Patent 1,753,517

    Method for the Production of Chemical and Pharmaceutical Products with integrated Multicolumn Chromatography
    J. Strube, K.U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen
  • EP Patent 1,795,174

    Liquid Distributor and Liquid Collector for Chromatography Columns
    G.H. Klepp, S. Böcker, J. Strube, H. Kansy, H. Schmale

2008

  • Sep. Sci. Technol. 43 (2008) No. 3, pp. 642-670

    Process Design Method for the Manufacturing of Natural Compounds and Related Molecules
    E. Ndocko, W. Bäcker, J. Strube
  • AIChE Journal 54 (2008) No. 11, pp. 2925-2942

    Design and Optimization of a Hybrid Distillation/Melt Crystallization Process
    M.B. Franke, N. Nowotny, E. Ndocko Ndocko, A. Gorak, J. Strube
  • Chem.-Ing.-Tech. 80 (2008) Nr. 9, pp. 1301-1301

    Entwurf und Auslegung von Phytoextraktionsprozessen - Standardapparatur und Modellierung
    M. Kaßing, F. Grote, J. Strube
  • Chem.-Ing.-Tech. 80 (2008) Nr. 9, pp. 1312-1313
    Integrierte Bioprozessentwicklung - Upstream, Downstream und "Downstream of Downstream"
    F. Grote, R. Ditz, J. Strube

2009

  • US Patent 7,615,159

    Method for the Production of Chemical and Pharmaceutical Products with integrated Multicolumn Chromatography
    J. Strube, K.U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen
  • US Patent 12/539,905
    Method for the Production of Chemical and Pharmaceutical Products with integrated Multicolumn Chromatography
    J. Strube, K.U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen
  • US Patent 8658040 B2
    Modular valve system for countercurrent chromatography process 
    J. Strube, KU Klatt, G Noeth, J Greifenberg, S Bocker, H Kansy, P Jahn, B. Justen
  • Chem.-Ing.-Tech. 81 (2009) Nr. 8, pp. 1064-1064

    Status der Fest-Flüssig-Extraktion von Pflanzenmaterial - Stand der Technik und Modellierung
    M. Kaßing, J. Strube, U. Jenelten, J. Schenk
  • Chem.-Ing.-Tech. 81 (2009) Nr. 8, pp. 1065-1065
    Methode zur effizienten Feedcharakterisierung für die Verfahrensentwicklung von komplexen Gemischen am Beispiel von Pflanzenextrakten
    J.P. Josch, W. Bäcker, J. Strube
  • Chem.-Ing.-Tech. 81 (2009) Nr. 8, pp. 1239-1239

    Integrierte Bioprozesse - Ökonomie als Innovationstreiber?
    R. Ditz,  F. Grote, J. Strube
  • Chem.-Ing.-Tech. 81 (2009) Nr. 8, pp. 1065-1065
    Kombination von hydrophober Interaktions- und Ionenaustauschchromatographie
    C. Borrmann, S. Sommerfeld, M. Lohrmann, J. Strube
  • Chem.-Ing.-Tech. 81 (2009) Nr. 8, pp. 1276-1277

    Downstream of Downstream Processing - Integrated Bioprocess Development from Upstream to Downstream
    F. Grote, R. Ditz,  J. Strube

2010

  • Chem. Eng. Technol. 33 (2010) pp. 377-387
    A New Approach for Process Development of Plant-Based Extraction Processes
    M. Kaßing, U. Jenelten, J. Schenk, J. Strube
  • Chem.-Ing.-Tech. 82 (2010) Nr. 9, pp. 1534-1534
    Integration von hydrophober Interaktions- und Ionenaustauschchromatographie
    C. Helling, C. Borrmann, S. Sommerfeld, M. Lohrmann, J. Strube
  • Chem.-Ing.-Tech. 82 (2010) Nr. 9, pp. 1542-1542
    Integrierte Prozessentwicklung - Bioproduktion der Zukunft?
    F. Grote, R. Ditz, J. Strube
  • Chem.-Ing.-Tech. 82 (2010) Nr. 9, pp. 1569-1569

    Auslegung von Bioextraktionsprozessen durch Prozessmodellierung in Kombination mit Miniplant-Versuchen am Beispiel der Antikörperaufreinigung
    J. E. Eggersglüß,  J. Strube
  • Chem.-Ing.-Tech. 82 (2010) Nr. 9, pp. 1571-1571
    Standardisierte Vorgehensweise zur Verfahrensausledung und -Optimierung von Phytoextraktionsprozessen
    R. Kerl, M. Kaßing, U. Jenelten, J. Schenk, J. Strube
  • Chem.-Ing.-Tech. 82 (2010) Nr. 9, pp. 1582-1582
    Methode zur effizienten Feedcharakterisierung für die Verfahrensentwicklung von komplexen Gemischen am Beispiel von Pflanzenextrakten
    J.P. Josch, W. Bäcker, J. Strube

2011

  • Chem.-Ing.-Tech. 83 (2011) Nr. 1-2, pp. 113-129

    New Material Design Strategy for Chromatographic Separation Steps in Bio-Recovery and Downstream Processing
    E. Ndocko Ndocko, J.P. Josch, R. Ditz, J. Strube
  • Chem.-Ing.-Tech. 83 (2011) Nr. 7, pp. 1044-1065
    Process Development and Design of Downstream Processes
    J. Strube, F. Grote, J. P. Josch, R. Ditz
  • Chem. Eng. Technol. 34 (2011) pp. 673-687
    Integration of Ultrafiltration Unit Operations in Biotechnology Process Design
    F. Grote, H. Fröhlich, J. Strube
  • Sep. Sci. Technol. 46 (2011) No. 8, pp. 1289-1305
    Phenomena and Modeling of Hydrophobic Interaction Chromatography
    C. Borrmann, C. Helling, M. Lohrmann, S. Sommerfeld, J. Strube
  • EP Patent 2,336,617
    Method for the Producing of Chemical and Pharmaceutical Products with integrated Multicolumn Chromatography
    J. Strube, K.U. Klatt, G. Nöth, J. Greifenberg, S. Böcker, H. Kansy, P. Jähn, B. Justen
  • John Wiley&Sons, Book: Industrial Scale Natural Products Extraction, Editor: H.-J. Bart, S. Pilz
    Process Engineering and Mini-Plant Technology
    J. Strube, W. Bäcker, M. Schulte
  • John Wiley & Sons, Book: Fluidverfahrenstechnik: Grundlagen, Methodik, Technik, Praxis, Editor: R. Goedecke

    Chromatographie
    J. Strube, M. Schulte, W Arlt

2012

  • Chem. Eng. Technol. 35 (2012) No. 1, pp. 109-132
    Combination of Rigorous ans Statistical Modeling for Process Development of Plant Based Extractions Based on Mass Balances and Biological Aspects
    M. Kaßing, U. Jenelten, J. Schenk, J. Strube
  • Chem. Eng. Technol. 35 (2011) No. 1, pp. 191-197
    Integration of Reverse-Osmosis Unit Operations in Biotechnology Process Design
    F. Grote, H. Fröhlich, J. Strube
  • J. Chem. Technol. Biochem. 87 (2012), No. 4, pp. 481-497
    Downstream of Downstream Processing: Development of Recycling Strategies for Biopharmaceutical Processes
    F. Grote, R. Ditz, J. Strube
  • John Wiley&Sons, Book: Biopharmaceutical Production Technology, Editor: G. Subramanian
    Modeling and Experimental Model Parameter Determination with Quality by Design (QbD) for Bioprocesses
    C. Helling, J. Strube
    Bioprocess Design and Production Technology for the Future
    J. Strube, F. Grote, R. Ditz
  • Chem. Eng. Technol. 35 (2011) No. 10, pp. 1786-1796

    Optimal Integration of Directly Combined Hydrophobic Interaction and Ion-Exchange Chromatography
    C. Helling, C. Borrmann, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 867-867
    Prädiktive Modellierung von Trennverfahren
    J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 868-874
    Die Produktbereiche der Vielstoffrektifikation
    A. Vogelpohl
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 875-879
    Separation Technologies 2030 - Are 100 Years of Chromatography Enough?
    R. Ditz
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 880-882
    Pflanzenextraktion: Schlüsseltechnologie zur nachhaltigen Nutzung von Bio-Ressourcen
    M. Tegtmeier
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 883-884
    Chemieanlagen der Zukunft - Unikate und/oder Module
    J. Lang, F. Stenger, R. Schütte
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 885-891
    Efficient Engineeing by Modularization into Package Units
    J. Rottke, F. Grote, H. Fröhlich, D. Köster, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 891-904
    Fundamentals towards a Modular Microstructured Production Plant
    C. Helling, H. Fröhlich, J. Eggersglüß, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 905-917
    Membrane Technology in Bioprocess Science
    H. Fröhlich, L. Villian, D. Melzner, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 6, pp. 918-931
    Characterization of Feed Properties for Conceptual Process Design Involing Complex Mixtures
    J. P. Josch, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1180-1180
    Deemulgation of Stabilized Emulsions through the Downstream Processing of Polyunsaturated Fatty Acids
    H. Fröhlich, K. Gasser, P. Quast, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1277-1277
    Multi-Stage Extraction in Microprocess Engineering
    T. Wellsandt, B. Stanisch, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1334-1334
    Quality-by-Design with Rigorous Process Modeling as Platform Technology of the Future
    C. Helling, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1335-1336
    Modell- und Miniplant-basierte Prozessentwicklung einer Proteinaufreinigung über wässrige Zweiphasenextraktion
    J. Eggersglüß, T. Wellsandt, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1336-1336
    Integration of Membrane Unit Operations in Bioprocess Design
    H. Fröhlich, C. Helling, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1349-1349
    Modeling and Design of Crystalization Processes of Natural Products
    I. Koudous, S. Both, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1350-1350
    Produktionstechnologie für Biologicals
    J. Strube, T. Peuker
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1350-1351
    Model-Based Design of Plant-Based Extraction Processes
    S. Both, C. Helling, U. Jenelten, S. Schenk, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1410-1410
    Conceptual Process Design and Optimization by Modeling in Combination with Miniaturized Laboratory Experiments
    S. Both, J.P. Josch, J. Strube
  • Chem.-Ing.-Tech. 84 (2012) No. 8, pp. 1416-1416
    Material by Design for Liquid Chromatography
    N. Kruse, R. Ditz, J. Strube
  • Food and Nutrition 3 (2012), pp. 836-850
    Characterization of Feed Properties for Conceptual Process Design Involving Complex Mixtures, Such as Natural Extracts
    J.P. Josch, S. Both, J. Strube
  • Chimica Oggi-Chemistry Today 30 (2012) No. 4, pp. 32-37
    Process development for the extraction of biomolecules - Application for downstream processing of proteins in aqueous two-phase systems
    J. Eggersgluess, S. Both and J. Strube
  • Biopharmaceutical Production Technology 1 & 2 (2012), pp. 409-443
    Modeling and Experimental Model Parameter Determination with Quality by Design for Bioprocesses
    C. Helling and J. Strube

2013

  • Chem.-Ing.-Tech. 85 (2013) No. 8, pp. 55-71
    Physical characterization of column chromatography: stringent control over equipment performance in biopharmaceutical production, Trends in Chromatography
    C. Helling, T. Dams, B. Gerwat, A. Belousov, J. Strube
  • Chem.-Ing.-Tech. 85 (2013) No. 8, pp. 1282-1289
    Resource‐Efficient Process Technology for Energy Plants
    S Both, C Helling, J Namyslo, D Kaufmann, B Rother, H Harling, J Strube
  • Chem.-Ing.-Tech. 85 (2013) No. 8, pp. 1272-1281
    Future Processing and Recycling Strategies for Rare Earths
    C Helling, J Strube
  • Chem.-Eng.-Technol. 36 (2013) No. 12, pp. 2125-2136
    Optimizing Established Processes like Sugar Extraction from Sugar Beets – Design of Experiments versus Physicochemical Modeling
    S. Both, J. Eggersglüß, A. Lehnberger, T. Schulz. T. Schulze, J. Strube
  • Ultrasonics Sonochemistry, pp. 1030-1034
    Extraction of polyphenols from black tea - conventional and ultrasound assisted extraction
    S. Both, F. Chemat, J. Strube

2014

  • Ind. Eng. Chem. Res., 53 (January 2014) No. 22, pp. 9169–9185
    Design and Operation of Continuous Countercurrent Chromatography in Biotechnological Production
    S. Zobel, C. Helling, R. Ditz and J. Strube
  • Comptes Rendus Chimie 17 (March 2014) No. 3, pp. 218-231
    Process design based on physicochemical properties for the example of obtaining valuable products from plant based extracts
    I. Koudous, S. Both, G. Gudi, H. Schulz, J. Strube
  • Chem.-Eng.-Technol. 37 (2014) No. 4, pp. 675-682
    Multi-Stage Aqueous Two-Phase Extraction for the Purification of Monoclonal Antibodies
    Jan K. Eggersgluess, Michael Richter, Michael Dieterle and Jochen Strube
  • “Green Extraction of Natural Products”. Wiley-VCH, Weinheim, 173-236.
    Panorama of Sustainable Solvents for Green Extraction Processes
    F. Chemat, J. Strube
  • Chem.-Ing.-Tech. 86 (2014) No. 9, pp. 1408
    Prozessentwicklung durch Integration von Upstream und Downstream Processing für biologisch aktive Substanzen
    P. Gronemeyer, J. Eggersglüß and J. Strube
  • Chem.-Ing.-Tech. 86 (2014) No. 9, pp. 1499
    Prozessintegration der Kristallisation in das Downstream-Processing von Pharmazeutika
    M. Lucke, I. Koudous and J. Strube
  • Chem.-Ing.-Tech. 86 (2014) No. 9, pp. 1453
    Entwicklung eines industrierelevanten Ansatzes zur Modellierung von Pervaporationen
    H. Thiess, B.C. Seyfang, T. Grützner and J. Strube
  • Chem.-Ing.-Tech. 86 (2014) No. 9, pp. 1491
    Integration der Prozessentwicklung von Upstream und Downstream Processing
    P. Gronemeyer and J. Strube
  • Chem.-Ing.-Tech. 86 (2014) No. 9, pp. 1504
    Integrated Counter Current Chromatography (iCCC) – Von der SMB zum integrierten Prozess
    S. Zobel, C. Helling and J. Strube
  • Bioengineering 1 (2014) No. 4, pp. 188,212
    Trends in Upstream and Downstream Process Development for Antibody Manufacturing
    P. Gronemeyer, R. Ditz and J. Strube
  • Comptes Rendus Chimie 17 (March 2014) No. 3, pp. 187-196
    Model-based equipment-design for plant-based extraction processes- considering botanic and thermodynamic aspects
    S. Both, I. Koudous, U. Jenelten, J. Strube
  • Chemie Ingenieur Technik 86 (2014) No. 5, pp. 687-694

    Efficient Engineering and Production Concepts for Products in Regulated Environments–Dream or Nightmare?
    J. Strube, R. Ditz, H. Fröhlich, D. Köster, T. Grützner, J. Koch, R. Schütte
  • Ultrasonics sonochemistry 21 (2014) No. 3, pp. 1030-1034

    Extraction of polyphenols from black tea–conventional and ultrasound assisted extraction
    S. Both, F. Chemat and J. Strube

  • Chemical Engineering & Technology 37 (2014) No. 10, pp. 1686-1696

    Integration of Aqueous Two‐Phase Extraction into Downstream Processing
    J. Eggersgluess, T. Wellsandt and J. Strube

2015

  • Chem.-Ing.-Tech. 87 (2015) No. 1-2, pp. 150-158
    Characterization Method for Separation Deices Based on Micro Technology
    T. Wellsandt, B.Stanisch and J. Strube
  • Chem.-Ing.-Tech. 87 (2015) No. 9, pp. 1198-1206
    Development of Micro Separation Technology Modules. Part 1: Liquid-Liquid Extraction
    T. Wellsandt, B.Stanisch and J. Strube
  • Chem.-Ing.-Tech. 87 (2015) No. 9, pp. 1207-1214
    Development of Micro Separation Technology Modules. Part 2: Distillation
    B.Stanisch, T. Wellsandt and J. Strube
  • Chem.-Ing.-Tech. 87 (2015) No. 8, pp. 1057-1058
    Purification of Antibodies and their Fragments by ATPE and Precipitation: One Step towards a Chromatography-Free Manufacturing Process
    P. Gronemeyer and J. Strube
  • BMC Proceedings 9 (2015) No. 9, pp. 39
    Technological and methodical process integration in manufacturing of monoclonal antibodies
    P. Gronemeyer and J. Strube
  • Chemical Engineering & Technology 38 (2015) No. 11, pp. 2025-2035
    Development of Purification Concepts for Nutraceuticals from Algae–Part I: Characterization of Emulsifying Components
    H. Fröhlich, K. Gasser, S. Gaul, T. Grützner and J. Strube
  • Chemical Engineering & Technology 38 (2015) No. 11, pp. 2035-2044
    Development of Purification Concepts for Nutraceuticals from Algae–Part II: Design of Purification Strategies
    H. Fröhlich, K. Gasser, S. Gaul, T. Grützner and J. Strube
  • Talanta 143 (2015), pp. 42-49
    Infrared and Raman spectroscopic methods for characterization of Taxus baccata L.–Improved taxane isolation by accelerated quality control and process surveillance
    G. Gudi, A. Krähmer, I. Koudous, J. Strube and H. Schulz
  • ZEITSCHRIFT FUR ARZNEI-& GEWURZPFLANZEN 19 (2015) No. 4, pp. 169-177
    Herbal Extract Production-From Evolution to Revolution
    S. Both, J. Strube and M. Tegtmeier
  • John Wiley&Sons, Book: Green extraction of natural products: theory and practice, Editor: F. Chemat, J. Strube
    Panorama of Sustainable Solvents for Green Extraction Processes
    I. Koudous, W. Kunz, J. Strube
  •  John Wiley&Sons, Book: Green extraction of natural products: theory and practice, Editor: F. Chemat, J. Strube
    Process Engineering and Product Design for Green Extraction
    S. Both, R Ditz, M Tegtmeier, U Jenelten, J. Strube
  • John Wiley&Sons, Book: Green extraction of natural products: theory and practice, Editor: F. Chemat, J. Strube
    Mass Transfer Enhancement for Solid–Liquid Extractions
    S. Both, J. Strube, G. Cravatto

2016

  • Comptes Rendus Chimie 19 (2016) No. 6, pp. 733-748
    Process design for integration of extraction, purification and formulation with alternative solvent concepts
    M. Sixt, I. Koudous and J. Strube
  • Bioengineering 3 (2016) No. 4,
    Purification of Monoclonal Antibodies Using a Fiber Based Cation-Exchange Stationary Phase: Parameter Determination and Modeling
    J Schwellenbach, S Zobel, F Taft, L Villain and J Strube
  • Biochemical Engineering Journal 113 (2016), pp. 158-166
    DoE based integration approach of upstream and downstream processing regarding HCP and ATPE as harvest operation
    P Gronemeyer, R Ditz and J Strube
  • Journal of Chromatography A 1447 (2016), pp. 92-106
    Preparation and characterization of high capacity, strong cation-exchange fiber based adsorbents
    J Schwellenbach, F Taft, L Villain and J Strube
  • Chimica Oggi-Chemistry Today 34(2016) No. 3, pp. 66-70
    Implementation of aqueous two-phase extraction combined with precipitation in a monoclonal antibody manufacturing process
    P Gronemeyer, R Ditz and J Strube
  • Biochemical Engineering Journal 113 (2016), pp. 158-166
    DoE based integration approach of upstream and downstream processing regarding HCP and ATPE as harvest operation
    P Gronemeyer, R Ditz and J Strube
  • Reactive and Functional Polymers 106 (2016), pp. 32-42
    Controlling the polymer-nanolayer architecture on anion-exchange membrane adsorbers via surface-initiated atom transfer radical polymerization
    J Schwellenbach, P Kosiol, B Sölter, F Taft, L Villain, J Strube

2017

  • Resource-Efficient Technologies, In Press (2017)
    Quality-by-Design (QbD) process evaluation for phytopharmaceuticals on the example of 10-deacetylbaccatin III from yew
    L. Uhlenbrock, M. Sixt and J. Strube
  • Resource-Efficient Technologies, In Press (2017)
    Pressurized hot water extracion of 10-deacetylbaccatin III from yew for industrial application
    M. Sixt and J. Strube
  • Journal of Membrane Science 522 (2017), pp. 292-302
    Passage of soft pathogens through microfiltration membranes scales with transmembrane pressure
    A. Helling, A. Kubicka, IAT Schaap, M. Polakovic, B. Hansmann, H. Thiess, J. Strube and V. Thom

  • Antibodies 6 (2017), 13
    Host Cell Proteins in Biologics Manufacturing: The Good, the Bad, and the Ugly
    M. Kornecki, F. Mestmäcker, S. Zobel-Roos, L. Heikaus de Figueiredo, H. Schlüter and J. Strube
  • Antibodies 6 (2017), 4
    Process Analytical Approach towards Quality Controlled Process Automation for the Downstream of Protein Mixtures by Inline Concentration Measurements Based on Ultraviolet/Visible Light (UV/VIS) Spectral Analysis
    S. Zobel-Roos, M. Mouellef, C. Siemers and J. Strube
  • Antibodies 6 (2017), 4
    Integradtion of Aqueous Two-Phase Extraction as Cell Harvest and Capture Operation in the Manufacturing Process of Monoclonal Antibodies
    A. Schmidt, M. Richter, F. Rudolph and J. Strube
  • Processes 5 (2017), 4
    Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.
    M. Sixt and J. Strube
  • Journal of Membrane Science 540 (2017), pp. 440-453
    Module design for ultrafiltration in biotechnology: Hydraulic analysis and statistical modeling
    H. Thiess, M. Leuthold, U. Grummert and J. Strube
  • John Wiley&Sons, Book: Continuous Biomanufacturing: Innovative Technologies and Methods, Editor: G. Subramanian
    • Engineering Challenges of Continuous Biomanufacturing Processes (CBP)
      H. Thiess, S. Zobel-Roos, P. Gronemeyer, R. Ditz, J. Strube
    • Continuous Chromatography as a Fully Integrated Process in Continuous Biomanufacturing
      S. Zobel-Roos, H. Thiess, P. Gronemeyer, R. Ditz, J. Strube
    • Integration of Upstream and Downstream in Continuous Biomanufacturing
      P. Gronemeyer, H. Thiess, S. Zobel-Roos, R. Ditz, J. Strube

2018

  • Membranes (2018)
    Development of a Scale-up Tool for Pervaporation Processes
    H. Thiess, A. Schmidt and J. Strube
  • Comptes Rendus Chimie (2018)
    In-line Raman spectroscopy and advanced process control for the extraction of anethole and fenchone from fennel (Foeniculum vulgare L. Mill.)
    M. Sixt, G. Gudi, H. Schulz and J. Strube
  • Antibodies (2018)
    Evaluation of Continuous Membrane Chromatography Concepts with an Enhanced Process Simulation Approach
    S. Zobel-Roos, D. Stein and J. Strube
  • Bioengineering (2018)
    Process Analytical Technology for Advanced Process Control in Biologics Manufacturing with the Aid of Macroscopic Kinetic Modeling
    M. Kornecki and J. Strube
  • Chemical Engineering Research and Design (2018)
    Integrating crystallization with experimental model parameter determination and modeling into cenceptual process design for the purification of complex feed muxtures
    M. Lucke, I. Koudous, M. Sixt, M. Huter and J. Strube
  • Processes (2018)
    Towards a Distinct and Quantitative Validation Method for Predictive Process Modelling-On the Example of Solid-Liquid Extraction Processes of Complex Plant Extracts
    M. Sixt, L. Uhlenbrock and J. Strube
  • Processes (2018)
    Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)
    M. Sixt and J. Strube
  • Processes (2018)
    Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L. - Part I: Conceptual Process Design and Cost Estimation
    M. Sixt, A. Schmidt, F. Mestmäcker, M. Huter, L. Uhlenbrock and J. Strube
  • Processes (2018)
    Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L. - Part II: Model-Based Design of Agitated and Packed Columns for Multistage Extraction and Scrubbing
    A. Schmidt, M. Sixt, M. Huter, F. Mestmäcker and J. Strube
  • Processes (2018)
    Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L. - Part III: Chromatographic Purification
    F. Mestmäcker, A. Schmidt, M. Huter, M. Sixt and J. Strube
  • Processes (2018)
    Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L. - Part IV: Crystallization
    M. Huter, A. Schmidt, F. Mestmäcker, M. Sixt and J. Strube
  • Processes (2018)
    Natural Products Extraction of the Future-Sustainable Manufacturing Solutions for Societal Needs
    L. Uhlenbrock, M. Sixt, M. Tegtmeier, H. Schulz, H. Hagels, R. Ditz and J. Strube
  • Chemical Engineering and Processing-Process Intensification (2018)
    Process Intensification in Biologics Manufacturing
    J. Strube, R. Ditz, M. Kornecki, M. Huter, A. Schmidt, H. Thiess, S. Zobel-Roos
  • Techno Scienze Publisher (2018)
    PAT AS KEY-ENABLING TECHNOLOGY FOR QBD IN PHARMACEUTICAL MANUFACTURING - A CONCEPTUAL REVIEW ON UPSTREAM AND DOWNSTREAM PROCESSING
    M. Kornecki, A. Schmidt, J. Strube
  • Wiley-VCH (2018)
    Application and Fundamentals of Liquid-Liquid Extraction Processes: Purification of Biologics, Botanicals, and Strategic Metals
    A. Schmidt, J. Strube

2019

  • Processes (2019)
    Accelerating Biologics Manufacturing by Modeling or: Is Approval under the QbD and PAT Approaches Demanded by Authorities Acceptable without a Digital-Twin?
    S. Zobel-Roos, A. Schmidt, F. Mestmäcker, M. Mouellef, M. Huter, L. Uhlenbrock, M. Kornecki, L. Lohmann, R. Ditz and J. Strube
  • Processes (2019)
    Accelerating Biologics Manufacturing by Upstream Process Modelling
    M. Kornecki and J. Strube

 

  • 1985 - 1992    Studium der Chemietechnik an der Universität Dortmund
  • 02/1992          Abschluß: Diplom-Ingenieur
  • 1992-1996     Wissenschaftlicher Mitarbeiter am Lehrstuhl für Anlagen-technik     der Abteilung Chemietechnik an der Universität Dortmund, Prof. Dr.-Ing. H. Schmidt-Traub

    Graduiertenförderungsstipendium des Landes NRW

    Max-Buchner-Forschungsstipendium, DECHEMA e.V.
  • 4/1996 Promotion zum Doktor-Ingenieur, Universität Dortmund

    ”Simulation und Optimierung kontinuierlicher Simulated Moving Bed (SMB)-Chromatographie-Prozesse”
  • 1996-1998 Oberingenieur und Habilitand Fachgebiet ”Prozeß- und Anlagentechnik” am Lehrstuhl für Anlagentechnik, Fachbereich Chemietechnik, Universität Dortmund

    Aufbau und Leitung der Arbeitsgruppe Adsorption/Chromatographie
  • 1998 Lehrpreis der Universität Dortmund, Fachbereich Chemietechnik
  • ab 1/1999 Mitarbeiter Bayer AG, Zentrale Technik - Technische Entwicklung – Fluidverfahrenstechnik, Extraktion und Chromatographie
  • 5/1999 Habilitation Fachbereich Chemietechnik, Universität Dortmund, Thema “Technische Chromatographie”, Venia Legendi “Verfahrenstechnik”
  • ab 1/2000 verantwortlich für Arbeitsgebiet Adsorption/ Chromatographie/Ionenaustausch: Betriebsanalysen, Verfahrensentwicklungen, Strategische Forschungs-projekte
  • bis 2/2006 technisch und wirtschaftlich verantwortlich für das Produkt Prozess Chromatographie Verfahrensentwicklung und Anlagenbau sowie strategische Forschungsprojekte Fluidverfahrenstechnik und Bioverfahrenstechnik
  • seit März 2006 Direktor des Institutes für Thermische Verfahrens- und Prozesstechnik der TU Clausthal
 

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